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Condition: Thrombosis
Vaccination: Vaccines
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Total 939 results found since Jan 2013.
Mitigating the risk of Tofacitinib-induced adverse events in the elderly population with Ulcerative Colitis
CONCLUSIONS: Modulation of induction dose and anti-thrombotic therapy may have contributed to prevent cardiologic events and thromboembolism. The introduction of zoster vaccine virtually eliminated zoster risk after the first cases. Potential malignancies deserve a careful work-up of older patients before treatment start.PMID:37702408 | DOI:10.1093/ecco-jcc/jjad158
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Anna Viola Raffaele Li Voti Chiara Bivacqua Clara de Francesco Marco Muscianisi Giuseppe Costantino Walter Fries Source Type: research
TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Link...
Source: This Week in Virology - MP3 Edition - August 20, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
PAD4-Induced NETosis Via Cathepsin G-Mediated Platelet-Neutrophil Interaction in ChAdOx1 Vaccine-Induced Thrombosis
CONCLUSIONS: Patients with VITT display enhanced thrombogenesis by PAD4-mediated NETs formation via cathepsin G-mediated platelet/neutrophil interaction.PMID:37586040 | DOI:10.1161/ATVBAHA.123.319522
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Roberto Carnevale Martina Leopizzi Marcello Dominici Giulia d'Amati Simona Bartimoccia Cristina Nocella Vittoria Cammisotto Alessandra D'Amico Valentina Castellani Francesco Baratta Alessia Bertelli Alessio Arrivi Danilo Toni Manuela De Michele Pasquale P Source Type: research
A summary of the Advisory Committee for Immunization Practices (ACIP) use of a benefit-risk assessment framework during the first year of COVID-19 vaccine administration in the United States
Vaccine. 2023 Jul 30:S0264-410X(23)00868-X. doi: 10.1016/j.vaccine.2023.07.037. Online ahead of print.ABSTRACTTo inform Advisory Committee for Immunization Practices (ACIP) COVID-19 vaccine policy decisions, we developed a benefit-risk assessment framework that directly compared the estimated benefits of COVID-19 vaccination to individuals (e.g., prevention of COVID-19-associated hospitalization) with risks associated with COVID-19 vaccines. This assessment framework originated following the identification of thrombosis with thrombocytopenia syndrome (TTS) after Janssen COVID-19 vaccination in April 2021. We adapted the be...
Source: Vaccine - August 1, 2023 Category: Allergy & Immunology Authors: Megan Wallace Hannah G Rosenblum Danielle L Moulia Karen R Broder Tom T Shimabukuro Christopher A Taylor Fiona P Havers Sarah A Meyer Kathleen Dooling Sara E Oliver Stephen C Hadler Julia W Gargano Source Type: research
Thrombosis with thrombocytopenia syndrome: A database review of clinical trial and post-marketing experience with Ad26.COV2.S
CONCLUSION: TTS induced by Ad26.COV2.S is very rare. Most co-occurring thrombosis with thrombocytopenia does not constitute TTS.PMID:37517912 | DOI:10.1016/j.vaccine.2023.07.013
Source: Vaccine - July 30, 2023 Category: Allergy & Immunology Authors: Frank Struyf Karin Hardt Rian Van Rampelbergh Georgi Shukarev Ajinkya Inamdar Javier Ruiz-Gui ñazú Vitalija van Paassen Luis Anaya-Velarde Camellia Diba Marc Ceuppens Vicky Cardenas Gerald A Soff Antoinette Pragalos Jerald Sadoff Macaya Douoguih Source Type: research
Re-evaluation of the risk of venous thromboembolism after COVID-19 vaccination using haematological criteria
Vaccine. 2023 Jun 7:S0264-410X(23)00662-X. doi: 10.1016/j.vaccine.2023.06.006. Online ahead of print.ABSTRACTAn elevated risk of venous thromboembolism (VTE) following a first dose of the ChAdOx1 adenovirus-vectored vaccine was found in a national epidemiological study in England using routine discharge diagnosis codes. Separately, the syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) was identified using haematological criteria based on presence of thrombocytopenia, significantly elevated D-dimers and development of anti-PF4 antibodies. To re-evaluate risk estimates using haematological criteria, we ob...
Source: Vaccine - July 26, 2023 Category: Allergy & Immunology Authors: Rebecca J Shaw Andrew J Doyle Emily A Millen Julia Stowe Elise Tessier Nick Andrews Elizabeth Miller HaemSTAR collaborators Source Type: research
Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis
Eur Heart J. 2023 Jul 13:ehad388. doi: 10.1093/eurheartj/ehad388. Online ahead of print.ABSTRACTPatients with severe infections and a pre-existing indication for antithrombotic therapy, i.e. antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical counselling among coagulation, infectious disease, and cardiology specialists, due to sepsis-induced coagulopathy that frequently occurs. Bacterial and viral pathogens constitute an increasing threat to global public health, especially for patients with ongoing antithrombotic treatment who have a high risk of thrombotic recurrences and high sus...
Source: Atherosclerosis - July 13, 2023 Category: Cardiology Authors: Bruna Gigante Jerrold H Levy Eric van Gorp Alessandro Bartoloni Marie-Luce Bochaton-Piallat Magnus B äck Hugo Ten Cate Christina Christersson Jos é Luis Ferreiro Tobias Geisler Esther Lutgens Sam Schulman Robert F Storey Jecko Thachil Gemma Vilahur Patr Source Type: research
Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia
CONCLUSIONS: Of the confirmed VITT patients (n=39), 17 (43.6%) had PF4-dependent antibodies and 22 (56.4%) had PF4-independent antibodies. CVST occurred almost exclusively in PF4-independent patients (11/22 vs. 1/17; p < 0.05). Additionally, PF4-independent antibodies bound to two distinct epitopes, the heparin-binding region and a site typical for heparin-induced thrombocytopenia antibodies, whereas PF4-dependent antibodies bound to only the heparin-binding region. These findings suggest that VITT antibodies that cause PF4-independent platelet activation represent a unique subset of patients more likely to be associate...
Source: Thrombosis and Haemostasis - July 2, 2023 Category: Hematology Authors: Angela Huynh Donald M Arnold Nikola Ivetic Rumi Clare Milena Hadzi-Tosev Yang Liu James W Smith Anna-Lise Bissola Mercy Daka John G Kelton Ishac Nazy Source Type: research
Long-term outcome in Vaccine-induced Immune Thrombocytopenia and Thrombosis
CONCLUSION: Once the acute episode of VITT has passed, patients appear to be at low risk for recurrent thrombosis and/or thrombocytopenia.PMID:37394120 | DOI:10.1016/j.jtha.2023.06.027
Source: Thrombosis and Haemostasis - July 2, 2023 Category: Hematology Authors: Linda Sch önborn Sabrina E Seck Thomas Thiele Lars Kaderali Till Hoffmann Annalena Hlinka Edelgard Lindhoff-Last Uwe V ölker Kathleen Selleng Alessandra Buoninfante Marco Cavaleri Andreas Greinacher Source Type: research
Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia
CONCLUSIONS: Of the confirmed VITT patients (n=39), 17 (43.6%) had PF4-dependent antibodies and 22 (56.4%) had PF4-independent antibodies. CVST occurred almost exclusively in PF4-independent patients (11/22 vs. 1/17; p < 0.05). Additionally, PF4-independent antibodies bound to two distinct epitopes, the heparin-binding region and a site typical for heparin-induced thrombocytopenia antibodies, whereas PF4-dependent antibodies bound to only the heparin-binding region. These findings suggest that VITT antibodies that cause PF4-independent platelet activation represent a unique subset of patients more likely to be associate...
Source: Thrombosis and Haemostasis - July 2, 2023 Category: Hematology Authors: Angela Huynh Donald M Arnold Nikola Ivetic Rumi Clare Milena Hadzi-Tosev Yang Liu James W Smith Anna-Lise Bissola Mercy Daka John G Kelton Ishac Nazy Source Type: research
Long-term outcome in Vaccine-induced Immune Thrombocytopenia and Thrombosis
CONCLUSION: Once the acute episode of VITT has passed, patients appear to be at low risk for recurrent thrombosis and/or thrombocytopenia.PMID:37394120 | DOI:10.1016/j.jtha.2023.06.027
Source: Thrombosis and Haemostasis - July 2, 2023 Category: Hematology Authors: Linda Sch önborn Sabrina E Seck Thomas Thiele Lars Kaderali Till Hoffmann Annalena Hlinka Edelgard Lindhoff-Last Uwe V ölker Kathleen Selleng Alessandra Buoninfante Marco Cavaleri Andreas Greinacher Source Type: research
Delta Variant of Covid-19 and Hearing Loss
Indian J Otolaryngol Head Neck Surg. 2023 Mar 29:1-3. doi: 10.1007/s12070-023-03724-2. Online ahead of print.ABSTRACTThe Coronavirus Disease of 2019 has now become one of the biggest pandemics of all time. Under the influence of ongoing mutations and widespread geographical expansions, several variants have been reported. Among those, the B.1.617.2 variant, most commonly known as the 'Delta variant' of the coronavirus disease - 19, was first reported in the state of Maharashtra of India in December 2020 and have currently been detected in over 43 countries across six continents around the globe. The B.1.617.2 variant of CO...
Source: Hand Surgery - June 26, 2023 Category: Surgery Authors: Abishek Umashankar Praveen Prakash Prashanth Prabhu Source Type: research
